The previously called noc n nitroso compounds measured by bingham s team in stools from red meat fed volunteers were according to bingham and kuhnle largely non n nitroso atnc apparent total nitroso compounds e g s nitrosothiols and nitrosyl iron as nitrosyl heme. N nitroso compounds are found in tanneries and plants manufacturing pesticides rubber products and tires.
Since that time n nitroso compounds have been shown in animal experiments to be the most broadly acting and the most potent group of carcinogens.
N nitroso compounds. It has a role as a carcinogenic agent. N nitroso compounds nocs include two chemical classes nitrosamines and nitrosamides which are formed by the reaction of amines and amides respectively with nitrosating agents derived from nitrite 1 4 nitrosamides which are direct alkylating agents that do not require metabolic activation 2 5 are potent neuro carcinogens in animal models especially through. Several hundred n nitroso compounds have been tested as carcinogens and over 80 have been found to be carcinogenic in at least 40 animal models eichholzer and guzwiller 1998.
In humans there is supporting evidence for a role of nocs in the cause of certain cancers such as gastric esophageal nasopharyngeal and colon cancers 2 3. Other workplaces where n nitroso compounds are found are fish processing plants foundries dye making plants and research labs. N nitroso compounds were known almost 40 years ago to be present in food treated with sodium nitrite which made fish meal hepatotoxic to animals through formation of nitrosodimethylamine ndma since that time n nitroso compounds have been shown in animal experiments to be the most broadly acting and the most potent group of carcinogens the key role of nitrite and nitrogen oxides in forming.
Nitrosamines are organic compounds of the chemical structure r 2 n n o where r is usually an alkyl group they feature a nitroso group no bonded to a deprotonated amine most nitrosamines are carcinogenic. N nitroso compounds nocs can induce cancer in about 40 different animal species including higher primates and are carcinogenic in multiple organs in animals. The n nitroso compounds fall into the category of carcinogens discovered through proposed industrial use barnes 1974.
N nitrososarcosine is a nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. In the early 1950s the then director of the medical research council s toxicology research unit the late dr. Swaffield to investigate possible toxic hazards from the proposed use of a presumed relatively biologically inert water.
Rubber baby bottle nipples and pacifiers may contain very small amounts of n. It is a non proteinogenic amino acid derivative and a nitrosamine. Barnes was asked by dr.
N nitroso compounds were known almost 40 years ago to be present in food treated with sodium nitrite which made fish meal hepatotoxic to animals through formation of nitrosodimethylamine ndma. Animal experiments have demonstrated n nitroso compounds to be the most potent and broadly acting carcinogens known ferguson 1999.